Serowe is an urban village in Botswana's Central District. A trade and commercial centre, it is Botswana's largest village.
Serowe is located in a fertile area, well-watered by the Lotsane River. It lies west of the Gaborone–Francistown road, from which it is easily reached. It also marks the beginning of the Serowe-Orapa road, which ends at the diamond mines in Orapa.
Notable features of the local area include a Botswana Defence Force (BDF) base on the road to Paje and the Khama Rhino Sanctuary. The Rhino Sanctuary is a charitable game reserve, 25 km north of Serowe, established in 1992 by the local Ballentine and Watson families and Ian Khama (the former President). Its 4,300 hectares of Kalahari sandveld were established as a haven for black and white rhinoceroses.