Keetmanshoop is the most important center of the Karakul sheep farming community in Namibia.

It is located in the Fish River Region of southern Namibia, lying on the Trans-Namib Railway from Windhoek to Upington in South Africa. It is named after Johann Keetman, a German industrialist and benefactor of the city.

Highlights in the area include a visit to the Naute Dam, the farm Spitskop Ost with its Mesoaurus fossils, the Giant's Playground, as well as the Quiver-tree forest, where visitors can view a rare cluster of the unique Aloe dichotoma and the Brukkaros Mountain a bit further north, an extinct volcano measuring 1,590 meters above sea level.